Mass Spectrometry Characterization of Difficult Samples

Learn about new mass spectrometry sample introduction technology

Direct analysis in real time mass spectrometry (DART-MS) is a proven technique that enables rapid analysis of both solid and liquid samples under standard laboratory conditions without sample preparation. However, certain polymers, cosmetic powders, and forensic materials are difficult to analyze using DART-MS due to the varying volatility of substituents in these complex samples.

To overcome these challenges, BioChromato developed an innovative sample introduction device (ionRocket), which gradually heats a sample placed directly beneath the DART-MS gas stream. Gradient heating of the sample before ionization creates time/temperature resolved mass spectra, separating species both by their thermal desorption profiles and mass to charge ratio (m/z). Even insoluble samples can be analyzed using the ionRocket / DART-MS set-up without pre-treatment.

Download the case study and technical backgrounder to learn how the BioChromato ionRocket can detect products from difficult samples.