--- title: Newly Developed Global Plasma Proteome Quantification Workflow description: Global plasma proteome quantification using internal standard triggered targeted analyses. image: https://go.labmanager.com/hubfs/LabManager/Downloads/Thermo/Research1600x900.png --- ![LabManager\_logo\_light](https://go.labmanager.com/hubfs/LabManager_logo_light.svg "LabManager_logo_light") [![LabManager\_logo](https://go.labmanager.com/hubfs/LabManager_logo.svg "LabManager_logo")](http://www.labmanager.com) # Newly Developed Global Plasma Proteome Quantification Workflow ![Research1800x900](https://go.labmanager.com/hs-fs/hubfs/LabManager/Downloads/Thermo/Research1800x900.png?width=1800&height=900&name=Research1800x900.png "Research1800x900") **Global plasma proteome quantification using internal standard triggered targeted analyses** The ability of plasma proteomics studies to deliver useful protein biomarkers has remained lower than initial expectations, prompting a redefinition of the plasma biomarker development pipeline. One proposed measure consisted in the implementation of a “rectangular” approach, relying exclusively on broad proteome profiling (through DDA or DIA analyses) across large cohorts for both the discovery and validation/verification stages. We describe here an alternative global quantification workflow, relying on a high density targeted acquisition method implemented on next generation Orbitrap mass spectrometers. This adaptation of the internal standard triggered PRM method leverages spiked-in stable isotopically labeled (SIL) peptides to drive the systematic screening of more than 500 plasma proteins per analysis across large sample sets. **Download this article, compliments of Thermo Fisher Scientific, to learn more about this novel global plasma proteome quantification workflow.** ## Download Now ![Thermo Fisher Scientific](https://go.labmanager.com/hs-fs/hubfs/Technology%20Networks/TN%20Email%20Campaigns%20and%20App%20Alerts/Email%20Campaigns/Thermo/18-06-2020/Thermo%20Fisher%20Scientific.jpg?width=350&name=Thermo%20Fisher%20Scientific.jpg)   Lab Manager needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at anytime. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, [check out our privacy policy by clicking here](https://www.labmanager.com/privacy-policy). ![LabManager\_logo](https://go.labmanager.com/hubfs/LabManager_logo.svg "LabManager_logo") [![Share on Facebook](https://go.labmanager.com/hubfs/lm_social_facebook-1.svg)](http://www.facebook.com/share.php?u=https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Dfacebook) [![Share on LinkedIn](https://go.labmanager.com/hubfs/lm_social_linkedin-1.svg)](http://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Dlinkedin) [![Share on Twitter](https://go.labmanager.com/hubfs/lm_social_twitter-1.svg)](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&url=https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&source=tweetbutton&text=Newly%20Developed%20Global%20Plasma%20Proteome%20Quantification%20Workflow) [![Share on Email](https://go.labmanager.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/email.png?width=24&name=email.png)](mailto:?subject=Check%20out%20https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Demail%20&body=Check%20out%20https%3A%2F%2Fgo.labmanager.com%2Fglobal-plasma-proteome-quantification%3Futm_medium%3Dsocial%26utm_source%3Demail) - [About Us](https://www.labmanager.com/about-us) - [Contact Us](https://www.labmanager.com/contact-us) - [Advertising](https://www.labmanager.com/advertising) - [Newsletters](https://www.labmanager.com/newsletters) - [Vendor List](https://www.labmanager.com/vendors) Now part of the LabX Media Group: [LabX Media Group](http://www.labxmediagroup.com/?__hstc=181257784.21576f6272bfcba3d16a5fb8fa824a1a.1570722952660.1580743078369.1580751779639.153&__hssc=181257784.4.1580751779639&__hsfp=2239469692) | [Clinical Lab Manager](http://www.clinicallabmanager.com/?__hstc=181257784.21576f6272bfcba3d16a5fb8fa824a1a.1570722952660.1580743078369.1580751779639.153&__hssc=181257784.4.1580751779639&__hsfp=2239469692) *Lab Manager* c/o LabX Media Group 1000 N West Street, Suite 1200, Wilmington, Delaware, USA, 19801  Toll-Free: 888-781-0328 | (705) 528-6888 Email: [privacy@labmanager.com ](mailto:privacy@labmanager.com)   © 2024 Lab Manager. All rights reserved.